醒脑静注射液对高血压脑出血患者临床指标的影响

Effect of Xingnaojing Injection on nitric oxide,insulin-like growth factor-1 and macrophage inhibitory factor of hypertensive patients with intracerebral hemorrhage

目的研究醒脑静注射液对高血压脑出血患者一氧化氮(NO)、胰岛素样生长因子-1(IGF-1)和巨噬细胞转移抑制因子(MIF)的影响。方法选择2012年1月至2014年10月在我院治疗的140例高血压脑出血且均成功进行了开颅或引流手术患者,随机分为对照组(72例)和试验组(68例)。对照组,静脉注射5%的葡萄糖注射液,每次280 m L,1次/天;试验组,在对照组的基础上,静脉滴注醒脑静注射液30 m L,1次/天,疗程15 d。通过硝酸还原酶法检测NO水平,酶联免疫吸附法检测IGF-1水平和放射免疫分析法检测MIF的表达水平。结果试验组总有效率为88.24%,显著高于对照组的72.22%(P<0.05)。试验组NO水平为(52.22±10.78)μmol·L^(-1)、IGF-1水平为(61.90±10.94)nmol·L^(-1),显著高于对照组患者的NO水平(36.23±8.14)μmol·L^(-1)和IGF-1水平(40.64±10.42)nmol·L^(-1);试验组患者的MIF水平为(44.34±12.52)ng·L^(-1),明显比对照组患者的MIF水平低(均P<0.05)。试验组患者并发症例数明显低于对照组(P<0.05)。结论醒脑静注射液不仅可以提高患者疗效,减少患者术后并发症发生,还可以升高血清IGF-1和NO的表达水平,降低血清MIF水平,对患者病情改善有明显促进作用。

Objective To investigate the effect of Xingnaojing Injection on nitric oxide（ NO）,insulin-like growth factor-1（ IGF-1） and macrophage inhibitory factor（ MIF） of patients with hypertensive intracerebral hemorrhage. Methods One hundred forty cases of patients with cerebral hemorrhage diagnosis were chose from January 2012 to October 2014 in our hospital. They were randomly divided into control group（ 72 cases）and treatment group（ 68 cases）. The patients in the control group was conventional treatment and infusion of glucose injection. On this basis,the treatment group were treated with 30 m L Xingnaojing injection. The NO was detected by nitrate reductase method. The IGF-1 was detected by enzyme-linked immunosorbent assay and the MIF expression levels was detected by radioimmunoassay. The last of complications in patients was statistical analyzed. Results Treatment group total effective rate was 88. 24%,significantly higher than 72. 22% of patients in controlgroup（ P〈0. 05）. NO levels in treatment group was（ 52. 22 ± 10. 78） μmol·L^-1,IGF-1 level was（ 61. 90 ± 10. 94）nmol·L^-1,NO and IGF-1 levels were significantly higher than in control group[（ 36. 23 ± 8. 14） μmol·L^-1and（ 40. 64 ±10. 42） nmol·L^-1]. MIF levels in treatment group was（ 44. 34 ±12. 52） ng·L^-1,significantly lower than in the control group of patients[（ 56. 92 ± 11. 36） ng·L^-1]（ P〈0. 05）. The complications number of patients in the treatment group was significantly lower than the control group patients（ P〈0. 05）. Conclusion Xingnaojing injection can not only improve patient outcomes,reduce postoperative complications in patients,can also increase the expression levels of serum IGF-1 and NO,reducing serum MIF levels,improve the condition of patients have significant role in promoting.