普萘洛尔治疗甲状腺功能亢进的Meta分析

Meta- analysis on the effects of propranolol for hyperthyroidism

目的系统评价普萘洛尔治疗甲状腺功能亢进的有效性。方法计算机检索Pub Med、Em Base、Cochrane library、Clinical trials、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普和万方数据库,收集普萘洛尔治疗甲状腺功能亢进的随机对照临床试验,并进行文献质量评价和资料提取,用Rev Man 5.3进行Meta分析。结果共纳入12项随机对照临床试验,974例患者。Meta分析结果显示,与对照组相比,试验组能显著提高甲状腺功能亢进的有效率(P<0.01),显著降低游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)水平(P<0.01)。在促甲状腺激素(TSH)水平上,试验组和对照组差异无统计学意义(P>0.05)。结论普萘洛尔可提高甲状腺功能亢进治疗有效率,并改善甲状腺功能亢进患者体内甲状腺激素水平。

Objective To assess the efficacy of propranolol for hyperthyroidism. Methods Studies were indentified by searching Pub Med,Em Base, Cochrane library, Clinical trials, China biology medicine（ CBM）,China National knowledge infrastructure（ CNKI）,VIP and Wan Fang database,randomized controlled trials（ RCT） of propranolol in the treatment of hyperthyroidism were included. After information collection and methodology quality evaluation,the Meta-analysis was performed using Rev Man 5. 3 software. Results A total of 12 studies and947 patients were included. The results of Meta-analysis indicated that compared with controlled studies,the treatment group is more effective（ P〈0. 01） and can decrease the serum free triiodothyronine（ FT3）level and free thyro-xine（ FT4） level（ P〈0. 01）. But no significant difference was found in thyroid-stimulating hormone（ TSH） level（ P〉0. 05）. Conclusion Propranolol can improve the response rate of hyperthyroidism and has positive effect on thyroid hormone levels.