新疆汉族乳腺癌与同型半胱氨酸及CBS G919A多态性的相关性

Correlation between G919A polymorphism of cystathionine β synthase and breast cancer in Han nationality in Xinjiang

目的:探讨新疆汉族乳腺癌患者血浆同型半胱氨酸(Hcy)及胱硫醚β合成酶(CBS)基因G919A多态性与乳腺癌的关系。方法:选取300例新疆汉族乳腺癌患者(乳腺癌组)和300例正常体检人群(正常对照组)为研究对象,采用扩张阻碍突变系统(ARMS)法检测研究对象CBS基因G919A多态性,采用自动生化分析仪检测研究对象血浆Hcy水平及相关生化指标,分析Hcy、CBS基因G919A多态性与乳腺癌的相关性。结果:新疆汉族乳腺癌患者血浆Hcy水平高于正常对照组(P<0.05),CBS G919A位点乳腺癌组基因型GG、GA、AA和等位基因G、A分别为63.7%、24.0%、12.3%和75.7%、24.3%,与对照组比较差异无统计学意义(P>0.05)。结论:Hcy水平升高可能是新疆汉族乳腺癌的危险因素之一,CBS G919A基因多态性与新疆患者乳腺癌的发生无相关性。

Objective To investigate the relationship between breast cancer and G919A polymorphisms of CBS （cystathionine β synthase） in patients with breast cancer in HaM nationality in Xinjiang. Method Three hundred breast cancer patients and 300 normal controls of HaM nationality were genotyped by ARMS method, and then the relative biochemical indicators were detected by the automatic biochemical analyzer. Results The Hcy level of breast cancer patients were higher than that of control group （P 〈 0.05）. Genotypes GG, GA, AA of CBS G919A and allele G,A, in breast cancer patients were 63.7%, 24%, 12.3% and 75.7%, 24.3% respectively, which had no statistically significance when compared with those of the controls （P 〉 0.05）. Conclusion The high level of Hcy may be a risk factor for breast cancer in HaM nationality in Xinjiang and there was no relationship between CBS G919A polymorphism and breast cancer.