活性氧在抗癌策略中的研究进展

Research progress of ROS in anticancer strategies

对肿瘤发展和抗癌策略而言,氧化压力的调控起着关键作用。许多与肿瘤发生相关的信号通路可以通过直接或者间接的机制来调控活性氧(ROS)。通常情况下,高水平的活性氧对细胞是有害的,而癌细胞的氧化还原态不同于正常细胞,且由于癌细胞的代谢和信号通路出现了畸变,因此癌细胞往往呈现高水平的活性氧。研究发现,高水平的活性氧在不同情况下对肿瘤发生可能起促进作用,同时也可能起到抑制肿瘤的作用。研究者可以利用这些看起来"矛盾"的效应来制定一些抗癌策略。

The regulation of oxidative stress plays a key role in tumor development and anticancer strategy. Many signaling pathways associated with tumorigenesis can regulate reactive oxygen species（ROS） through direct or indirect mechanism. Generally, high levels of ROS lead to cellular damage but the redox state of cancer cells is different from normal cells. And because of aberrated metabolic and signaling pathways, cancer cells often show high levels of ROS. The studies have found that high levels of ROS may block or promote tumorigenesis. Researchers can make some anticancer strategies based on these ＂contradictory＂ effect.