低氧刺激影响PGC-1α表达研究进展

Regulation of PGC-1α by hypoxic stimulation

过氧化物酶体增殖物激活受体γ共激活因子-1α(peroxisome proliferator activated receptorγcoactivator-1α,PGC-1α)是参与调控机体线粒体发生、糖脂代谢、适应性产热、肌纤维类型转化等生理过程的关键转录共激活分子。而低氧刺激可通过代偿激活一系列细胞应答机制,促发机体不同组织PGC-1α表达及其介导的细胞信号调控通路重新调整,进而改变机体整个能量代谢体系。本文通过总结低氧浓度、低氧时长等多种刺激因素影响不同组织PGC-1α表达的相关研究,旨在进一步揭示不同组织PGC-1α对其低氧刺激产生代偿适应的分子机制,从而更好地解释低氧刺激下机体PGC-1α在调控全身能量代谢稳态中的重要作用。

Peroxisome proliferator activated receptor γ coactivator-1α（PGC-1α） is a key transcriptional coactivator which regulates the mitochondrial biogenesis, glucose and lipid metabolism, adaptive thermogenesis, transformation of muscle fibers. A series of mechanisms of cell response can be triggered by the compensatory of hypoxic stimulation, to make different organization change of PGC-1α and modulate cell signaling pathways which are mediated by PGC-1α, finally to change energy metabolism system. We herein summarize the research which is about the expression of PGC-1α that is affected by hypoxic concentration, hypoxic time, and explore the adaptive compensatory mechanism of the PGC-1 of different organization for the hypoxic stimulation, to explain the importance of the PGC-1α in the energy homeostasis for the hypoxic stimulation better.