MMP-9、HIF-1和SIRT1在急性肺损伤中的研究进展

MMP-9, HIF-1 and SIRT1 in acute lung injury： a review

基质金属蛋白酶-9（matrix metalloproteinase，MMP-9）9是MMPs家族成员之一，参与炎症、血管形成和肿瘤侵袭转移等病理生理过程。低氧诱导因子-1（hypoxia—induciblefactor，HIF-1）是具有转录活性的核蛋白，由功能亚基HIF—1α和结构亚基HIF-1β组成的异源二聚体，它在缺血坏死后新生血管的形成和低氧诱导的细胞凋亡过程当中起着非常关键的作用。沉默信息调节因子2相关酶1（silent information regulator2-related enzymes 1，Sirtuin1，SIRT1）是一种烟酰胺腺嘌呤二核苷酸（nicotinamide adenine dinucletide, NAD）依赖性的去乙酰化酶，属于Sirtuin蛋白家族成员之一，参与衰老、细胞死亡和肿瘤发生等病理生理过程。本文就MMP-9、HIF-1和SIRT1在急性肺损伤中所起作用的最新研究进展作一综述。

Matrix metallopeptidase 9 （MMP-9） is a group of enzymes that belong to the zine- metalloproteinases family involved in the pathophysiological process of various diseases, such as inflammation, angiogenesis and tumor invasion. Hypoxia-inducible factor-1 （HIF-1） is a nucleoprotein with transcription aetivity, which consists of two different subunits, c~ and [3. It plays an important role in the process of the formation of new blood vessels following ischemic necrosis and the process of hypoxia induced cell apoptosis. Silent information regulator2-related enzymes 1 （SIRT1） is a NAD-dependent deacetylase sirtuin, which belongs to a member of the sirtuin family of proteins, also involved in many pathophysiologic processes, such as aging, cell death and tumorigenesis. This study aims to review the role of MMP-9, HIF-1 and SIRT1 in acute lung injury.