CK19表达与子宫颈癌前哨淋巴结转移的关系被引量：4

Relationship between the Expression of CK19 and Sentinel Lymph Node Metastasis of Cervical Cancer

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摘要目的观察CK19表达与子宫颈癌前哨淋巴结转移的关系。方法回顾性分析行宫颈癌根治术治疗的46例宫颈癌患者的临床资料,采用mRNA和免疫组化检测CK19在子宫颈前哨淋巴结中的表达。结果 RT-PCR分析结果显示82个淋巴结中,11个淋巴结CK19高表达,71个淋巴结CK19低表达。免疫组化染色结果显示,11个CK19高表达淋巴结免疫组化染色阳性,71个CK19低表达淋巴结免疫组化染色阴性。多因素分析结果表明CK19高表达与前哨淋巴结转移呈正相关(P<0.05)。结论 CK19表达与宫颈癌患者淋巴结转移呈正相关,CK19有可能称为宫颈癌转移的分子标记物。 Objective To detect the relationship between the expression of CK19 and sentinel lymph node metastasis of cervical cancer. Methods The clinical data of 46 patients with cervical cancer treated by radical resection were retrospectively analyzed. The expression of CK19 in sentinel lymph node metastasis of cervical cancer was detected by mRNA and immunohistochemistry. Results RT-PCR analysis showed that in 82 lymph nodes,there were 11 lymph nodes with high expression of CK19, 71 lymph nodes with low expression of CK19. Immunohistochemical staining showed that 11 CK19 high expression lymph nodes were positive for immunohistochemical staining,71 CK19 low expression lymph nodes were negative for immunohistochemical staining. Multivariate analysis showed that CK19 expression was positively correlated with sentinel lymph node metastasis （ P 〈 0.05）. Conclusion CK19 expression is positively correlated with lymph node metastasis in patients with cervical cancer. CK19 may be a molecular marker for cervical cancer metastasis.

作者李琳邢辉覃小敏周敏

机构地区湖北文理学院医学院襄阳市中心医院

出处《实用癌症杂志》 2016年第3期387-389,共3页 The Practical Journal of Cancer

关键词细胞角蛋白19 子宫颈癌前哨淋巴结转移 CK19 Cervical cancer Sentinel lymph node Metastasis

分类号 R737.33 [医药卫生—肿瘤]

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1Reichert M, Rustgi AK. Pancreatic ductal cells in develop- ment, regeneration, and neoplasia [J]. J Clin Invest, 2011, 121 (12) :4572-4578.
2Han X,Zhao J,Ji Y, et al. Expression of CK19 and KIT in resectable pancreatic neuroendocrine tumors [J]. Tumour Biol,2013,34(5 ) :2881-2889.
3Zand B, Euscher ED, Soliman PT, et al. Rate of para-aortic lymph node micrometastasis in patients with locally ad- vanced cervical cancer[J]. Gynecol Oncol, 2010,119 ( 3 ) : 422-425.
4Diaz JP, Gemignani ML, Pandit-Taskar N, et al. Sentinel ly- mph node biopsy in the management of early-stage cervical carcinoma [J].Gynecol Oncol, 2011,120 ( 3 ) :347-352.
5Khoury-Collado F, Murray MP, Hensley ML, et al. Sentinel lymph node mapping for endometrial cancer improves the detection of metastatic disease to regional lymph nodes[J].Gynecol Oncol, 2011,122 ( 2 ) : 251-254.
6Hertel H. Cervical cancer and the role of lymph node stag- ing cons sentinel concept [J]. Int J Gynecol Cancer,2010,20( 11 Suppl 2) :$37-38.
7Matsuura N1, Uchinaka A, Mori S. A novel diagnostic meth- od for detection of lymph node metastases[J]. Nihon Geka Gakkai Zasshi ,2013,114 ( 1 ) :4-8.
8American Joint Committee on Cancer:AJCC Cancer Staging Manual [ M].6th ed, New York : Springer, 2002 : 157-164.
9Pappa KI1, Jacob-Hirsch J, Vlachos GD, et al. Expression profiling of vulvar carcinoma : clues for deranged extracellu- lar matrix remodeling and effects on multiple signaling pathways combined with discrete patient subsets[J]. Transl Oncol,2011,4(5) :301-313.
10McCoy A, Finan MA, Boudreaux FT, et al. The incidence and clinical significance of lymph node micrometastases de- termined by immunohistochemical staining in stage I-lymph node negative endometrial cancer[J].Histol Histopathol, 2012,27(2) :181-185.