不同化疗方案对晚期卵巢癌治疗效果的对比

Comparison of Different Chemotherapy for Advanced Ovarian Cancer

目的对比TC与TP方案应用于初次接受手术后化疗的晚期卵巢癌患者中的临床疗效及不良反应的差异。方法回顾性选取2011年1月-2014年12月晚期卵巢癌患者165例,TC方案组85例,TP方案组80例,收集其完整病例资料,对2组患者的治疗效果与不良反应情况进行对比分析。结果 TC方案组的临床有效率明显高于TP组,差异具有统计学意义(P<0.05)。TC方案组的治疗总的生活质量改善程度明显高于TP组,差异具有统计学意义(P<0.05);与TP组比较,TC组治疗期间的血小板下降明显高于TP组,但均不严重;恶心呕吐及肝肾功能毒性明显低于TP组,差异有统计学意义(P<0.05)。结论 TC方案治疗晚期卵巢癌可取得较好的临床疗效,不良反应相对较少,耐受程度高,对延长生存时间,改善患者生活质量具有重要意义。

Objective To compare the clinical efficacy and adverse reactions of TC and TP for advanced ovarian cancer. Methods Retrospective analysis of 165 cases of patients with advanced ovarian cancer were conducted. TC group had 85 cases, and TP group had 80 cases. The complete medical information of all patients were collected, and clinical efficacy and adverse reactions of the 2 groups were analyzed. Results The clinical effectiveness of TC group was obviously higher than TP group, and the difference was statistical significant （ P 〈 0.05 ）. The overall quality of life of TC group was superior to TP group （ P 〈 0.05 ） ; Compared with TP group, the rate of platelet decline during treatment in TC group was obviously higher than TP group, but the condition were not serious. The rate of nausea and vomiting,liver and kidney toxicity in TC group were lower than TP group, and the differences were statistically significant （ P 〈 0.05）. Conclusion Chemotherapy with TC for advanced ovarian cancer is effective with relatively small side effects and high degree of tolerance. It is of great significance to prolong the survival time and improve quality of life of patients.