序贯疗法治疗胃溃疡50例临床观察

Clinical Observation of Quadruple Therapy and Sequential Therapy in the Treatment of Gastric Ulcer

目的:观察序贯疗法治疗胃溃疡的临床疗效。方法:将100例胃溃疡患者随机分为两组,每组50例。观察组采取序贯疗法;对照组采取四联疗法,比较两组溃疡愈合率、Hp根除率、不良反应发生率。结果:观察组溃疡愈合率为84.00%,显著高于对照组的66.00%(P<0.05);观察组Hp根除率为92.00%,明显高于对照组的66.00%(P<0.01);两组不良反应发生率比较无显著差异(P>0.05)。结论:序贯疗法较四联疗法在根除幽门螺旋杆菌,促进溃疡愈合方面优势突出。

Objective To investigate the efficacy of quadruple therapy and sequential therapy in the treatment of gastric ulcer. Methods 100 cases of patients with gastric ulcer in our hospital from January 2014 to June 2015 were selected and randomly divided in- to two groups, 50 cases in each group. Patients in the observation group were treated with Sequential therapy while patients in the con- trol group were treated with quadruple therapy. The ulcer healing rate, HP eradication rate and adverse reaction incidence of two groups were compared. Results The ulcer healing rate of the observation group was 84.00%, which was significantly higher than that （66. 00% ） of the control group （ P 〈 0.05 ） ; the eradication rate of Hp was 92.00%, which was significantly higher than that （ 66.00% ） of the control group （ P 〈0. 01 ）, and the incidence of adverse reactions in the two groups was not significantly different （ P 〉 0. 05）. Conclusion Compared to quadruple therapy, Sequential therapy has the advantage in the treatment of Helicobacter pylori e- radication and of promoting ulcer healing.