奥氮平预防化疗所致恶心呕吐的疗效观察被引量：4

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摘要目的观察奥氮平预防化疗所致恶心呕吐的疗效。方法收集180例化疗患者,分为观察组和对照组,各90例。两组均在化疗前30 min给予静脉滴注昂丹司琼针8 mg+奥美拉唑针40 mg减轻胃肠道反应;观察组自化疗第1天开始早晚各口服奥氮平5 mg,连用5 d。观察两组患者恶心呕吐的发生情况及其他不良反应。结果观察组和对照组急性恶心呕吐的发生率分别为38.89%(35/90)和60.00%(54/90),两组差异有统计学意义(<0.05);观察组和对照组迟发性恶心呕吐的发生率分别为13.33%(12/90)和51.11%(46/90),两组差异有统计学意义(<0.05);两组食欲下降发生率差异有统计学意义(<0.05);其他两组差异均无统计学意义(均>0.05)。结论奥氮平对化疗患者预防恶心呕吐具有较好的疗效,尤其对迟发性恶心呕吐疗效更明显。

作者王师沈燕萍兰朋训王华英俞万钧

机构地区宁波市鄞州人民医院

出处《现代实用医学》 2016年第1期18-19,38,共3页 Modern Practical Medicine

关键词奥氮平化疗恶心呕吐

分类号 R730.5 [医药卫生—肿瘤]

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