依那普利联合氯沙坦治疗早期2型糖尿病肾病合并高血压的疗效与安全性

Clinical effect and safety of Enalapril and Losartan in the treatment of early stage of type 2 diabetic nephropathy complicated with hypertension

目的探讨依那普利联合氯沙坦治疗早期2型糖尿病肾病合并高血压的疗效与安全性。方法选取2013年3月~2015年3月进行治疗的2型糖尿病肾病合并高血压患者62例,随机分为观察组和对照组,各31例,对照组仅采用氯沙坦治疗,观察组采用依那普利联合氯沙坦进行治疗,对比两组患者的临床疗效。结果治疗后,两组患者的收缩压和舒张压均显著降低（P〉0.05）,两组患者的血肌酐、尿素氮及24 h尿微量蛋白排泄率指标均较治疗前显著降低,观察组患者明显低于对照组（P〈0.05）。结论依那普利联合氯沙坦治疗早期2型糖尿病肾病合并高血压患者疗效显著,安全性高,值得临床推广。

Objective To explore the clinical effect and safety of Enalapril and Losartan in the treatment of early stage of type 2 diabetic nephropathy complicated with hypertension. Methods 62 patients of type 2 diabetic nephropathy complicated with hypertensiontreated from March 2013 to March 2015 were selected and randomly divided into observation group and control group, 31 cases each group. The control group adopted Losartan; the observation group adopted Enalapril and Losartan. The curative effect for two groups was compared.Results After treatment, the systolic and diastolic blood pressure was significantly lower than before（P 0.05）; the index of Scr, BUN and 24-hour UAER for observation group was even lower than that of control group（P 0.05）. Conclusion Enalapril and Losartan have an obvious effect and higher safety in the treatment of early stage of type 2 diabetic nephropathy complicated with hypertension. It is worthy of clinical promotion.