温阳活血方治疗慢性肾脏病疗效观察

Clinical observation on Wenyanghuoxue treatment of chronic kidney disease

目的观察温阳活血方治疗慢性肾脏病的疗效。方法选取2013年6月~2014年6月收治的196例慢性肾脏病患者,随机分为对照组与观察组,每组98例,对照组给予常规西医治疗,治疗组在对照组基础上给予温阳活血方治疗。治疗12周后,比较两组患者血清肌酐（Scr）、24 h尿蛋白定量（24 h UP）、肾小球滤过率（e GFR）与尿素氮（BUN）。结果两组患者的Scr、24 h UP、BUN水平较治疗前均降低（P〈0.05）,且观察组降低更加明显（P〈0.05）;两组患者的e GFR较治疗前均升高,但对照组差异无统计学意义（P〉0.05）;观察组的总有效率显著高于对照组。结论温阳活血方安全有效,可减少蛋白尿,降低血清Scr、BUN水平,升高e GFR,改善患者症状,延缓慢性肾脏病的进程。

Objective To investigate the Clinical observation on Wenyanghuoxue treatment of chronic kidney disease. Methods From June 2013 to June 2014, 196 patients with chronic kidney disease were randomly divided into the control group and the observation group, each of 98 cases. The control group was received conventional western medicine treatment, on the basis of control gToup.The observation group was received Wenyanghuoxue treatment. After 12 weeks treatment , serum creatinine （Scr）, 24 h urinary protein excretion （24 hUP）, glomerular filtration rate （eGFR） and blood urea nitrogen （BUN） of the two groups were compared. Results Scr, 24hUP, BUN levels of the two groups were lower than before treatment （P 〈 0.05 ）, while the observation group was more obvious （P 〈 0.05 ） ; eGFR of two groups were higher than before treatment, but the control group does not have a statistically difference （P 〉 0.05 ）, the observation group with a statistically difference （P 〈 0.05）. Conclusion Wenyanghuoxue treatment is safe and effective, can reduce proteinuria, decrease serum Scr, BUN levels, increase glomerular filtration rate, improve chronic kidney disease symptoms, delay progression of chronic kidney disease.