右美托咪定复合舒芬太尼术后镇痛对子宫切除患者皮质醇水平和免疫功能的影响

Effect of postoperative analgesia of dexmedetomidine combined with sufentanil on cortisol levels and immune function of patients with hysterectomy

目的探讨右美托咪定复合舒芬太尼术后镇痛对子宫切除患者皮质醇水平和免疫功能的影响。方法择期子宫切除术患者116例,随机分为2组。A组接受舒芬太尼术后自控镇痛,B组接受右美托咪定复合舒芬太尼术后自控镇痛。记录两组术毕0、2、24h皮质醇水平和免疫功能的变化。结果 A组患者皮质醇水平明显高于B组(P<0.05),IgG、IgA、IgM及CD4^+T细胞含量低于B组,CD8^+T细胞含量高于B组(P<0.05)。结论右美托咪定复合舒芬太尼术后镇痛可更好地降低应激,改善患者皮质醇水平,增强免疫功能。

Objective To explore the effect of postoperative analgesia of dexmedetomidine combined with sufentanil on cortisol levels and immune function in patients with hysterectomy.Methods A total of 116 patients with hysterectomy were divided into two groups randomly according to different patient-controlled intravenous analgesia scheme.Patients in group A recieved sufentanil patient-controlled intravenous analgesia,and patients in group B accepted dexmedetomidine combined with sufentanil patient-controlled intravenous analgesia.Cortisol levels and immune function were compared between the two groups at 0,2 and 24 h after operation.Results Compared with group B,the cortisol level in group A was higher（P 〈 0.05）,and the contents of IgG,IgA,IgM and CD4~＋ T cells were lower with higher level of CD8~＋ T cells（P 〈 0.05）.Conclusion Postoperative analgesia of dexmedetomidine combined with sufentanil can decrease the stress,improve the cortisol levels,and enhance immune function.