叶酸缺乏与出生缺陷相关性研究进展

Research progress on the correlation between folic acid deficiency and birth defects

叶酸缺乏可导致胎儿神经管畸形、先天性唇腭裂、高同型半胱氨酸血症,还和某些出生缺陷的发生、发展有密切关系。本文对叶酸的生理功能、代谢途径与出生缺陷的相关性及叶酸代谢酶基因多态性与出生缺陷相关性等方面进行综述。

Folic acid deficiency can lead to fetal neural tube defects,congenital cleft lip and palate,hyperhomo cysteinemia with a close relationship to the occurrence and development of certain birth defects.In this paper,the physiological function of folic acid,metabolic pathway,the correlation between birth defects and folic acid,and the correlation between birth defects and gene polymorphism of folate metabolism enzyme are summarized.