全面触发工具在药物不良事件检测中的应用

Application of the Global Trigger Tool in detecting adverse drug events

药物不良事件（ADE）是威胁患者安全的主要因素。目前我国医疗机构主要依靠自发呈报方法检测ADE，该方法检出率低，不能反映临床用药安全的真实情况。全面触发工具（GTT）是一项较新的ADE检测方法。通过阐述GTT的发展历史、基本原理、操作程序、国内外研究和应用现状以及与其他检测方法比较，说明GTT是一项高效、实用的ADE检测方法，并适用于评价各类医疗机构的临床用药安全情况，还能针对特定科室、特定人群发生的ADE进行检测，从而帮助医疗机构获知更多有关临床用药安全的证据。

Adverse Drug Event（ADE）is a major hetor threatening patient safety. For now, the ADE detecting in China mostly relies on spontaneous reporting, a method detecting only a small proportion of ADEs, instead of reflecting the real-world clinical medication safety. Global Trigger Tool （GTT） is a relatively new method for detecting ADEs, This paper described the GTT as an effective and practical method for detecting ADEs, by introducing the history of GTT development, GTT basic principles, operating procedures, current relevant researches and application at home and aboard and comparing with other ADE detection methods. The GTT can evaluate the clinical medication safety in various medical institutions, In particular, it can target specific clinical departments or certain people to detect ADEs for obtaining more evidences of clinical medication safety. That is the reason that we recommend medical institutions at all levels learn and use GTT,