含有氨基酸结构单元的手性γ-丁内酯衍生物的合成及结构表征

Synthesis and Structural Characterization of Chiral γ-Butyrolactone Containing Amino Acid Building Block

在K_2CO_3和相转移催化剂TBAB存在下,氨基酸酯与手性源(R)-5-(l-氧基)-2(5H)-呋喃酮于室温下反应,得到一系列具有氨基酸结构组分的手性γ-丁内酯化合物。所有合成化合物的结构通过红外、核磁共振、高分辨质谱等进行了确认,并通过底物结构、反应规律以及产物的核磁共振氢谱分析,确认了新形成手性中心的绝对构型。

A series of chiral γ-butyrolactones containing amino acid building block were synthesized via the reaction of amino acid ester with chiral synthon（ R）-5-（ l-menthnol）-2（ 5H）-furanone in the presence of K_2CO_3 and phase transfer catalysis TBAB at room temperature. All the products were confirmed by IR,~1HNMR,^（13）CNMR,and HR-MS,and the absolute configuration of the stereogenic center was confirmed through the structure of the substrate,reaction regularity and ~1HNMR analysis.