摘要
以D-天冬氨酸为原料,依次通过酯化、酰化、N-甲基化和水解四步反应制得标题化合物,并对酯化和N-甲基化的反应条件进行了考察和优化,使反应总产率达到82.1%,并且产品的纯度与光学纯度均高于98%,从而避免了手性拆分,降低了生产成本,更适合工业化生产。
N-methyl-D-aspartic acid was prepared through a four-step reaction of esterification,acylation,methylation and hydrolysis from D-aspartic acid used as a starting material. The reaction conditions of esterification and N-methylation were investigated and optimized. The overall yield of this method was 82. 1% and HPLC purity( including optical purity) more than 98%,which can avoid chiral resolution and reduce the production cost. Therefore,this method is more suitable for industrial production.
出处
《化学试剂》
CAS
北大核心
2016年第3期280-282,286,共4页
Chemical Reagents
基金
贵州省高等学校化学药物研发工程中心项目(黔教合KY字[2014]219)
贵阳医学院药物化学重点实验室项目(GYZD[2014]001)
贵州省科技厅-贵州医科大学联合基金(黔科合LH字[2015]7340)