2015版WHO肺肿瘤组织学分类解读

Fourth edition of WHO classification of tumours of the lung,published in 2015

对第4版(2015年)WHO肺肿瘤分类与第3版(2004年)肿瘤分类进行比较,并复习相关文献。2015版肿瘤分类作了大量的改动,对肺肿瘤的分类做了一些修改,新增了6个病种,即NUT中线癌、肌上皮肿瘤、伴有EWSR1-CREB1基因易位的肺黏液样肉瘤、血管内大B细胞淋巴瘤、Erdheim-Chester病和脑膜瘤非特异型;更新了肺癌的分子病理和免疫组织化学等内容,强调了肺癌相关基因的检测与靶向治疗。对一些肿瘤作了重新命名,如硬化性血管瘤命名为硬化性肺泡细胞瘤,使用贴壁型腺癌代替原先的细支气管肺泡癌。

To compare 4th edition of WHO Classification of Tumours of the Lung （published in 2015） and 3rd edi- tion （published in 2004） and review relevant literature. The 4th edition not only incorporated a great number of changes but also newly added 6 tumors entities, ie： NUT carcinoma, myoepithelial tumours, pulmonary myxoid sarcoma with EWSR1-CREB1 translocation,intravascular large B-cell lymphoma, Erdheim-Chester disease, Meningioma NOS, as well as updated the contents of molecular pathology and immunohistochemistry of lung cancer, emphasizing detection of lung cancer relate genes and targeted therapies, renamed some of the tumours, for example, sclerosing haemangioma replaced by sclerosing pneumocytoma,using the term lepidic adenocarcinoma for formerly bronchioloalveolar carcinoma.