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长链非编码RNA在神经胶质瘤中作用的研究进展 被引量：4

Progress of research in the role of lncRNA in gliomas
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摘要 长链非编码RNA(lncRNA)是一类新的非编码调节基因,目前研究发现lncRNA可以在3个方面调节基因表达。它的表达受遗传物质改变的影响,并在神经胶质瘤细胞增殖、凋亡,细胞侵袭,细胞分化,血管再生等方面起着一定作用。LncRNA可以作为神经胶质瘤诊断的生物学标志,并作为神经胶质瘤的治疗靶点及辅助神经胶质瘤的治疗。 The latest research shows that long non-coding RNAs（lncRNA） gene regulators, can regulate gene expression in 3 aspects. The changes regarded as a new class of non-coding the hereditary material can affect ln- cRNA gene expression and lncRNA may contribute to the proliferation and apoptosis, the invasiveness and differen- tiation of glioma cells, and to angiogenesis. LncRNA can serve as novel biomarkers and therapeutic targets to help diagnose and treat gliomas.
作者 王一 李学民 柳琛
机构地区 新疆医科大学第一附属医院神经外科 新疆医科大学语言文化学院
出处 《基础医学与临床》 CSCD 2016年第3期411-414,共4页 Basic and Clinical Medicine
关键词 长链非编码RNA 神经胶质瘤 long non-coding RNA gliomas
分类号 R739.41 [医药卫生—肿瘤]
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参考文献20

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二级参考文献10

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共引文献5

同被引文献44

引证文献4

二级引证文献13

基础医学与临床
2016年 第3期

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