CT-1和IL-6在阻塞性睡眠呼吸暂停低通气综合征患者中的改变及临床意义

Change and clinical significance of serum cardiotrophin-1 and IL-6 levels in patients with obstructive sleep apnea-hypopnea syndrome

目的检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清心肌营养素-1(CT-1)和白细胞介素-6(IL-6)的变化,探讨CT-1和IL-6与OSAHS患者病情的相关性。方法设置OSAHS组(n=58)和对照组(n=50),测定并比较血清CT-1和IL-6的变化,分析其与OSAHS的相关性。结果 OSAHS组血清CT-1和IL-6水平均要高于对照组;OSAHS患者血清CT-1与AHI呈正相关;IL-6与最低血氧饱和度呈负相关;而血清CT-1和IL-6间无相关性;同时血清CT-1和IL-6在轻度、中度、重度OSAHS患者中差异有统计学意义(P<0.05);血清CT-1和IL-6在年龄、性别、是否吸烟等分布上差异无统计学意义(P>0.05),而在体质量超重、饮酒或高血压的OSAHS患者中相对较高。结论血清CT-1和IL-6可用于反应OSAHS患者病情的严重程度。

Objective To detect the change of serum CT-1and IL-6levels in the patients with obstructive sleep apnea-hypopnea syndrome（OSAHS）and to investigate the relation between the CT-1and IL-6with the disease condition of OSAHS.Methods Serum CT-1and IL-6levels were detected and compared between 58 patients with OSAHS and 50 healthy controls.Their relation with OSAHS was analyzed.Results The serum CT-1and IL-6levels in the OSAHS group were higher than those in the control group;the serum CT-1and IL-6levels was positively correlated with AHI,and the IL-6level was negatively correlated with LSaO2;serum CT-1had no correlation with IL-6;meanwhile serum CT-1and IL-6levels had statistical difference among mild,moderate and severe OSAHS（P〈0.05）,while had no statistical difference in the distributions of the age,sex and whether smoking（P〉0.05）,but which were relatively higher in the OSAHS patients with over body weight,drinking or hypertension.ConclusionThe serum CT-1and IL-6levels can be used to reflect the severity of OSAHS.