干扰素治疗小儿乙肝临床效果观察

Investigation of the effect of interferon on the treatment of infantile hepatitis B

目的探讨干扰素治疗小儿乙肝的临床效果。方法将100例小儿乙肝患者按照治疗方法不同分为两组,各50例。对照组给予苦参素治疗,观察组给予干扰素α-2b治疗,比较两组临床效果及不良反应。结果治疗6个月后,观察组HBV-DNA阴转率高于对照组(P<0.05),总胆红素和谷丙转氨酶均低于对照组(P<0.05或P<0.01);两组患儿均无严重不良反应发生。结论干扰素治疗小儿乙肝临床效果显著,能有效改善患儿肝功能,且安全性好,值得临床推广应用。

Objective To observe and analyze the value of interferon in the treatment of infantile hepatitis B. Methods One hundred cases of pediatric patients with hepatitis B were divided into two groups according to different treatment methods,50 cases in either group. Patients in the control group used sophora while those in the observation group were given interferon alpha-2b. Results6 months after treatment,negative rate of HBV- DNA in the observation group was higher than that in the control group（ P 〈 0. 05）and total bilirubin and ALT level were lower than those in the control group（ P 〈 0. 05 or P 〈 0. 01）. Conclusion Interferon has significant curative effect in the treatment of infantile hepatitis B,and it can improve the patients’ liver function and can be widely used in clinical treatment.