胃腺癌中PYGOPUS2和PTEN的表达及相关性研究

Study on expressions and relationship of PYGOPUS2 and PTEN in gastric adenocarcinoma

目的检测胃腺癌中PYGOPUS2和PTEN的表达特点,探讨二者在不同临床特征中表达的意义。方法以95例胃腺癌作为观察组,以70例非肿瘤的胃黏膜组织作为对照组,采用免疫组织化学方法检测2组中PYGOPUS2和PTEN的表达。结果观察组中PYGOPUS2表达的阳性率明显高于对照组(P<0.05),PTEN表达的阳性率明显低于对照组(P<0.05)。观察组中PYGOPUS2和PTEN的表达均与淋巴结转移、脉管浸润和Ki67表达密切相关(P均<0.05)。PYGOPUS2的表达与肿瘤的直径和分化程度密切相关(P均<0.05),而PTEN的表达与肿瘤的直径和分化程度无明显相关性。线性相关分析显示PYGOPUS2和PTEN的表达未见明显相关性。生存分析显示PYGOPUS2和PTEN的表达与预后相关(P均<0.05)。结论胃腺癌组织中PYGOPUS2高表达、PTEN低表达对肿瘤的发生和进展均有一定促进作用,PYGOPUS2和PTEN之间未见明显协同作用。术后联合检测PYGOPUS2和PTEN的表达对判断胃腺癌的预后有一定价值。

Objective It is to detect the expressions of PYGOPUS2 and PTEN in gastric adenocarcinoma, and investigate their significance on different clinical characteristic. Methods The study included 95 cases of gastric adenocarcinoma as obser- vation group, 70 cases of normal gastric tissue as control group. The expressions of PYGOPUS2 and PTEN were detected by IHC methods and analyzed in two groups. Results In the observation group, the positive rate of PYGOPUS2 was significantly higher and the positive rate of PTEN was significantly lower than those in the control group （ all P 〈 0.05）. The positive rate of PYGOPUS2 and PTEN were correlated with lymph node metastasis, vascular invasion and Ki67 expression （ all P 〈 0.05）. The positive rate of PYGOPUS2 was correlated with tumor volume and differentiation （ all P 〈 0.05 ） , but the positive rate of PTEN was not correlated with tumor volume and differentiation. There was not relationship between PYGOPUS2 and PTEN in gastric adenocareinoma. The expressions of PYGOPUS2 and PTEN were correlated with prognosis in gastric adenocarcinoma （ all P 〈 0.05 ）. Conclusion The higher-expression of PYGOPUS2, lower-expression of PTEN may promote the occurrence and development of gastric adeuocarcinoma. There is no obvious synergy between PYGOPUS2 and PTEN in neoplasms. The joint detection of PYGOPUS2 and PTEN may be helpful to predict prognosis of gastric adenocarcinoma.