期刊文献+

PLA2G6基因与帕金森病 被引量:9

原文传递
导出
摘要 帕金森病(Parkinson’s disease)是常见的神经退行性疾病之一,经流行病学调查显示,我国65岁以上人群帕金森病的发病率为1.7%,其临床表现主要为静止震颇、运动迟缓、肌强直、姿势步态异常及非运动症状等。目前其病因及发病机制尚不完全明确,可能与老化、环境、遗传等因素相关。
出处 《中华神经科杂志》 CAS CSCD 北大核心 2016年第2期145-149,共5页 Chinese Journal of Neurology
基金 国家自然科学基金资助项目(81371405)
  • 相关文献

参考文献50

  • 1] Zhang ZX, Roman GC, Hong Z, et al. Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai [ J ]. Lancet, 2005, 365(9459) : 595-597.
  • 2Verstraeten A, Theuns J, Van Broeckhoven C. Progress in unraveling the genetic etiology of Parkinson disease in a genomic era[J]. Trends Genet, 2005, 31 (3) : 140-149. DOI: 10. 1016/ j. tig. 2015.01. 004.
  • 3Funayama M, Ohe K, Amo T, et al. CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study [ J ]. Lancet Neurol, 2015, 14 ( 3 ) : 274-282. DOI: 10. 1016/S1474-4422(14)70266-2.
  • 4Wilson GR, Sire JC, McLean C, et al. Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkiuson disease with ct-synuclein pathology[ J]. Am J Hum Genet, 2014, 95 (6) : 729-735.
  • 5Paisan-Ruiz C, Bhatia KP, Li A, et al. Characterization of PLA2G6 as a locus for dystonia-parkinsonism [ J ]. Ann Neurol, 2009, 65( 1 ) : 19-23. DOI: 10. 1002/ana. 21415.
  • 6Winstead MV, Balsinde J, Dennis EA. Calcium-independent phospholipase A2 : structure and function [ J ]. Biochim Biophys Acta, 2000, 1488 (1-2) : 28-39.
  • 7Allyson J, Bi X, Baudry M, et al. Maintenance of synaptic stability requires calcium-independent phospholipase A2 activity [ J]. Neural Plast, 2012, 2012: 569149. DOI: 10. 1155/2012/ 569149.
  • 8Balsinde J, Balboa MA. Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells [ J]. Cell Signal, 2005, 17 (9) : 1052-1062.
  • 9Green JT, On" SK, Bazinet RP. The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids [ J ]. J Lipid Res, 2008, 49(5) : 939-944. DOI: 10. l194/jlr. R7OOO17-JLR200.
  • 10Balboa MA, Varela-Nieto I, Killermann Lucas K, et al. Expression and function of phospholipase A ( 2 ) in brain [ J ]. FEBS Lett, 2002, 531(1) : 12-17.

同被引文献16

引证文献9

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部