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瘦素调节糖代谢的机制研究进展 被引量:2

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摘要 随着糖尿病发病形势的日趋严峻,糖尿病治疗方法的突破和创新也迫在眉睫。除了经典的口服降糖药和胰岛素治疗外,许多针对新的治疗靶点尤其是分子生物学靶点的药物也应运而生,其中瘦素被认为是一个潜在的有效治疗药物。上世纪90年代初,研究发现某些肥胖鼠血中缺少一种可有效阻止大鼠发生肥胖症和糖尿病的重要物质。
作者 朱冰 曲伸
出处 《中华糖尿病杂志》 CAS CSCD 2016年第2期72-74,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
基金 中华医学会临床医学科研专项基金(120120550355) 上海市卫生局申康慢病综合防治项目(SHDC12012303)
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  • 1Fujikawa T, Berglund ED, Pate1 VR, et al. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin[J]. Cell Metab, 2013,18(3):431-444. DOI: lO.1016/j. cruet.2013.08.004.
  • 2Vong L, Ye C, Yang Z, et al. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons[J]. Neuron, 2011,71(1):142-154. DOI:IO.1111/j.1748- 1716.2007.01784.x.
  • 3Berglund ED, Vianna CR, Donato J Jr, et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice[J]. J Clin Invest,2012,122 (3):1000-1009. DOI: 10.1172/JCI59816.
  • 4Fujikawa T, Chuang JC, Sakata I, et al. Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice[J]. Proe Natl Acad Sci U S A, 2010,107 (40):17391-17396. DOI: lO.1073/pnas.1008025107.
  • 5Yu X, Park BH, Wang MY, et al. Making insulin-deficient type 1 diabetic rodents thrive without insulin[J]. Proe Natl Aead Sei U S A, 2008,105(37):14070-14075. DOI: 10.1073/ pnas.0806993105.
  • 6German JP, Wisse BE, Thaler JP, et al. Leptin deficiency causes insulin resistance induced by uncontrolled diabetes[J]. Diabetes, 2010,59(7):1626-1634. DOE 10.2337/db09-1918.
  • 7Denroche HC, Levi J, Wideman RD, et al. Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling[J]. Diabetes, 2011,60(5):1414-1423. DOI: 10.2337/db10-0958.
  • 8Hedbacker K, Birsoy K, Wysocki RW, et al. Antidiabetic effects of IGFBP2, a leptin-regulated gene[J]. Cell Metab, 2010,11(1):11-22. DOI: 10.1016/j.cmet.2009.11.007.
  • 9Cummings BP, Bettaieb A, Graham JL, et al. Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats[J]. Proc Natl Acad Sci U S A, 2011,108(35):14670-14675. DOI: 10.1073/ pnas.1107163108.
  • 10Wang MY, Chen L, Clark GO, et al. Leptin therapy in insulin- deficient type I diabetes[J]. Proc Natl Acad Sci U S A, 2010, 107(11):4813-4819. DOI: 10.1073/pnas.0909422107.

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