摘要
肝细胞癌是高发病率和高死亡率的恶性肿瘤，治疗的关键在于早期诊断。DNA甲基化是表观遗传学最为重要的机制之一，探讨DNA甲基化致癌机制的改变可为肝细胞癌诊断提供理论依据，同时特定基因的甲基化水平也可作为生物标志物用于肝细胞癌早期诊断和预后评估。
Hepatocellular carcinoma （HCC） is a malignant tumor with high morbidity and high mortality. Early diagnosis is the key for HCC treatment. DNA methylation is one of the important mechanisms of epigenetic genetics. To investigate the mechanism of DNA methylation can provide a theoretical basis for the diagnosis of HCC, and the methylation level of the specific genes can also be used as the biomarkers of HCC for the early diagnosis and prognosis evaluation.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2016年第2期79-81,共3页
Chinese Journal of Laboratory Medicine
基金
国家自然科学基金(81502557)National Natural Science Foundation of China
关键词
癌
肝细胞
DNA甲基化
早期诊断
预后
肿瘤标记
生物学
Carcinoma, Hepatocellular
DNA Methylation
Early Diagnosis
Prognosis
Tumor Markers, Biological
