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胃食管反流病与特发性肺纤维化 被引量:10

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摘要 特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种致死性、呈进行性发展的肺部疾病,缺乏有效治疗手段,确诊后平均生存期仅2~3年[1].目前认为肺泡上皮细胞持续损伤导致的异常组织修复是IPF的主要发病机制.但导致肺泡上皮损伤的病因不明,这是IPF治疗陷入困境的重要原因.近年研究发现胃食管反流(gastroesophageal reflux disease,GERD)可能是IPF的潜在病因,2011年IPF循证医学新指南中已将GERD列入IPF发病的主要危险因素之一[2],现就GERD与IPF的相关研究进展综述如下.
作者 陈碧 蒋捍东
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2016年第2期137-139,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 国家自然科学基金面上项目(81274143)
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参考文献28

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二级参考文献22

  • 1Michele Cicala,Sara Emerenziani,Michele Pier Luca Guarino,Mentore Ribolsi.Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease[J].World Journal of Gastroenterology,2013,19(39):6529-6535. 被引量:39
  • 2Xiang-Huai Xu,Zhong-Min Yang,Qiang Chen,Li Yu,Si-Wei Liang,Han-Jing Lv,Zhong-Min Qiu.Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough[J].World Journal of Gastroenterology,2013,19(27):4386-4392. 被引量:20
  • 3林三仁,许国铭,胡品津,周丽雅,陈旻湖,柯美云,袁耀宗,房殿春,萧树东.中国胃食管反流病共识意见[J].胃肠病学,2007,12(4):233-239. 被引量:528
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