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浆细胞瘤转化迁移基因1在肿瘤中的研究进展

Plasmacytoma variant translocation 1 in cancer
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摘要 浆细胞瘤转化迁移基因（PVT1）是一个重要的长非编码RNA,在人类基因组PVT1定位于染色体8q24.21.PVT1的异常表达和多态性与人类多种肿瘤如恶性淋巴瘤、乳腺癌、结直肠癌、胰腺癌等密切相关,并能影响肿瘤患者的生存和预后.目前认为其作用机制可能是通过与Myc基因、微小RNA或其他蛋白的相互作用,以及基因多态性等,但还不明确,对PVT1的深入研究有望为肿瘤的诊断治疗提供新靶点. Plasmacytoma variant translocation1 （PVT1） is a very important long nocoding RNA,which located at chromosome 8q24.21 in human beings.Aberrant expression and polymorphism of PVT1 was closely associated with various kinds of cancers such as malignant lymphoma,breast cancer,colorectal cancer,pancreatic cancer,and affected survival and prognosis of cancer patients.This mainly attribute to its interactin with myc,miRNAs and other proteins,and also gene polymorphism.Further study of PVT1 is expected to provide a new target for the diagnosis and treatment of cancer.
作者 彭娟菲 张世能
机构地区 中山大学孙逸仙纪念医院消化内科
出处 《国际肿瘤学杂志》 CAS 2016年第2期141-144,共4页 Journal of International Oncology
基金 国家自然科学基金(81572348) National Natural Science Foundation of China
关键词 肿瘤 浆细胞瘤转化迁移基因1 PLASMACYTOMA VARIANT TRANSLOCATION 1 Neoplasms
分类号 R730.2 [医药卫生—肿瘤]
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国际肿瘤学杂志
2016年 第2期

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