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Unilateral Internal Carotid Artery Occlusion After Letrozole Treatment in a Postmenopausal Woman with Breast Cancer

Unilateral Internal Carotid Artery Occlusion After Letrozole Treatment in a Postmenopausal Woman with Breast Cancer
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摘要 To the Editor: Letrozole, a third-generation aromatase inhibitor (AlL is a relatively newer class of endocrine agents used in hormone-receptor-positive breast cancer Vascular thrombotic events, such as acute myocardial infarction and acute cerebral infarction, in patients with breast cancer after initiation of letrozole therapy have been documented in the literature However, the impact of this adjuvant endocrine therapy on increasing tile risk of developing vascular tbrombotic events has been a controversial issue. Here, we report a rare case of a woman with breast cancer developing unilateral internal carotid artery (ICA) occlusion alier letrozole treatment. To the Editor: Letrozole, a third-generation aromatase inhibitor (AlL is a relatively newer class of endocrine agents used in hormone-receptor-positive breast cancer Vascular thrombotic events, such as acute myocardial infarction and acute cerebral infarction, in patients with breast cancer after initiation of letrozole therapy have been documented in the literature However, the impact of this adjuvant endocrine therapy on increasing tile risk of developing vascular tbrombotic events has been a controversial issue. Here, we report a rare case of a woman with breast cancer developing unilateral internal carotid artery (ICA) occlusion alier letrozole treatment.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第4期494-495,共2页 中华医学杂志(英文版)
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参考文献5

  • 1Breast lntemational Group (BIG) 1 - 98 Collaborative Group, Thirlimann B, Keshaviah A, Coates AS, Mouridsen H, Mauriac L, Forbes JF, et al. A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med 2005;353:2747-57. doi: 10.1056/NEJMoa052258.
  • 2Canpolat U, Sunman H, Kaya EB, Aytemir K, Oto A. Myocardial infarction due to coronary thrombus formation in a postmenopausal woman with breast cancer after initiation of letrozol therapy. Int J Cardiol 2012;160:el-2. doi: 10.1016/j.ijcard.2011.12.071.
  • 3Digklia A, Voutsadakis IA. Acute eerebrovascular accident after cisplatin treatment in a patient taking letrozole. Chemotherapy 2012;58:435-8. doi: 10,1159/000345793.
  • 4Smith 1E, Dowsett M. Aromatase inhibitors in breast cancer. N Engl J Med 2003;348:2431-42. doi: 10.1056/NEJMra023246.
  • 5Bell LN, Nguyen AT, Li L, Desta Z, Henry NL, Hayes DF, et al. Comparison of changes in the lipid profile ofpostmenopausal women with early stage breast cancer treated with exemestane or letrozole. J Clin Pharmaco12012;52:1852-60. doi: 10.1177/0091270011424153.

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