胃癌组织中B7-H1的表达及临床意义研究

Expression of B7-H1 protein in gastric cancer and its clinical significance

目的检测人体胃癌组织中B7-H1的表达,探讨其与患者临床病理特征的关系及对预后的影响。方法采用免疫组化染色法检测胃癌组织中B7-H1的表达,分析其在胃癌组织中的阳性表达率与患者临床病理特征之间的关系,并绘制患者术后生存曲线,评价B7-H1表达对预后的影响。结果 65例胃癌组织中癌细胞的细胞膜、细胞质以及部分肿瘤组织浸润的淋巴管及淋巴细胞中均有检测到B7-H1的阳性表达,阳性率为36.9%。有淋巴结转移或脉管内有癌栓的患者B7-H1阳性率较高(均P<0.05)。B7-H1阳性表达的胃癌患者术后5年生存率(25.0%)低于阴性表达的患者(56.1%)(P<0.05)。结论 B7-H1阳性表达的胃癌患者易发生淋巴结转移,预后较差,B7-H1可作为评价胃癌患者预后的指标之一。

Objective To investigate the expression of B7-H1 in gastric carcinoma and its clinicopathological significance. Methods Immunohistochemical staining was used to detect the expression of B7-H1 protein in gastric cancer. The relationship between the B7-H1 protein expression and clinicopathological parameters was analyzed. Results Immunohistochemical staining revealed that B7-H1 was expressed on membrane, cytoplasm of cancer cells and tumor infiltrating lymphocytes. B7-H1 protein in gastric cancer was correlated with lymph node metastasis and vessel infiltration （P〈0.05）. The postoperative 5-year survival rate of patients with negative B7-H1 expression （25.0%） was lower than that of those with positive B7-H1 expression （56.1%, P〈0.05）. Conclusion Gastric cancer patients with B7-H1 positive expression are likely to have lymph node metastasis and poor prognosis, indicating that it might be used as an indicator of prognosis for gastric cancer patients.