STAT6免疫组织化学染色在孤立性纤维瘤／脑膜血管外皮瘤诊断中的应用价值探讨

Diagnostic value of STAT6 immunohistochemistry in solitary fibrous tumor/meningeal hemangiopericytoma

目的探讨STAT6免疫组织化学染色在孤立性纤维瘤（SFT）／脑膜血管外皮瘤（HPC）诊断中的作用。方法运用免疫组织化学染色检测37例sgr／脑膜HPC、30例脑膜瘤和30例神经鞘瘤中STAT6、波形蛋白、CD34、上皮细胞膜抗原、孕激素受体、S-100蛋白、CD56、胶质纤维酸性蛋白（GFAP）、Ki-67的表达情况。结果所有SFT／脑膜HPC瘤细胞细胞核对STAT6均呈强阳性表达，阳性肿瘤细胞所占比例大约为60％～95％，各病例之间无明显差异；波形蛋白均呈强阳性表达；CD34阳性表达占32例；上皮细胞膜抗原阳性表达为1例；孕激素受体阳性表达为4例；S-100蛋白、CD56及GFAP均呈阴性表达；Ki-67阳性指数1％～8％不等。然而，脑膜瘤和神经鞘瘤对STAT6均呈阴性表达。结论STAT6是SFT／脑膜HPC的一种比较特异的生物学标志物，建议可常规运用于SFW脑膜HPC的诊断和鉴别诊断中，特别对于不典型病例的鉴别诊断可发挥十分重要的作用，并为SFT／脑膜HPC的精确病理诊断提供新的选择和帮助。

Objective To investigate the diagnostic role of STAT6 immunohistochemistry in solitary fibrous tumors （SFF）/meningeal hemangiopericytomas （HPC）. Method Evaluated the expression of STAT6, vimentin, CD34, EMA, PR, S-100, CD56, GFAP and Ki-67 in a cohort of 37 SFT/meningeal HPC, 30 meningiomas and 30 schwannomas by immunohistochemistry staining. Results All SFT/ meningeal HPC demonstrated nuclear positivity for STAT6, and the proportion of positive tumor cells ranged from 60% to 95%, with no significant difference cases. Vimentin was strongly positive in all cases. CD34, EMA and PR positivity was found in 32 cases, 1 case and 4 cases, respectively. S-100 protein, CD56 and GFAP were negative; Ki-67 labeling index was 1% - 8%. However, the meningiomas and schwannomas were negative for STAT6. Conclusions STAT6 is a relatively specific biomarker for SFT/meningeal HPC, and may be used in the diagnosis and differential diagnosis of SFT/meningeal HPC, especially for the atypical cases, and allows the precise pathologic diagnosis of SFT/meningeal HPC.