中度高海拔地区人群血清叶酸与EPO的关系探讨

The relationship between serum folate and EPO in people living in moderate altitude area

目的探讨中度高海拔地区人群叶酸营养水平与促红细胞生成素的关系。方法以2014年1月至2014年8月来自云南省弥勒市三个镇(海拔>1 000 m)的健康人群485例为研究对象,进行问卷调查、体格检查,同时进行血常规、血清促红细胞生成素(EPO)、血脂四项以及血清叶酸检测,按照血清叶酸浓度将研究对象分为高、中、低血清叶酸组,运用多变量一般线性模型以及Spearman秩相关分析,分析叶酸和EPO之间的关联性。结果中度高海拔地区人群,在低、中、高血清叶酸浓度组间,血清EPO水平不同,差异具有统计学意义(P<0.05);LDL-C在三组间差异也具有统计学意义(P<0.05);而RBC,Hb,TC,TG,HDL-C水平在三组间的差异无统计学意义(P>0.05);血清叶酸浓度与EPO呈正相关关系(rs=0.731,P<0.001),与Hb呈负相关关系(rs=-0.101、P<0.05),与RBC的相关系数无统计学意义。结论中度高海拔人群的血清叶酸浓度与血清EPO明显相关,血清叶酸浓度高者其血清EPO也较高,提示保持良好的叶酸营养状况有益于中度高海拔地区人群维持血清高EPO水平。

Objective To explore the relation between the levels of serum folate and erythropoietin（EPO）in healthpeople living in moderate altitude area. Methods A total of 485 subjects from three towns（1 000 meters above sea level）ofMile city in Yunnan province were recruited during January 2014 to August 2014. Subjects were asked to completecomprehensive questionnaires and physical examinations. Serum folate,EPO and lipids profile had been tested. Then subjectswere divided into three groups according to the concentration of serum folate. Multivariate General Linear Model and Spearmanrank correlation analysis were applied for evaluating the relation between serum folate and EPO. Results In moderatealtitude area,among the subjects of three groups,EPO and LDL-C had significant difference（P〈0.05）,while RBC,Hb,TC,TG,HDL-C had not（P〉0.05）. Moreover,the correlation between serum folate and EPO,and Hb had statistical significancerespectively（rs= 0.731 and-0.101,P〈0.001 and P〈0.05）. Otherwise the correlation between serum folate and RBC had notstatistical significance（P〉0.05）. Conclusion In moderate altitude area,serum folate is significantly associated with EPO.The people with higher serum folate concentration have higher levels of EPO,thus suggesting adequate folate intake could helpto maintain the high levels of EPO.