祛瘀消痛贴膏联合美施康定对癌性疼痛患者疼痛缓解及生活质量的影响

Effect of Quyu Xiaotong plaster combined with morphine sulfate on cancerous pain and quality of life

目的:观察祛瘀消痛贴膏联合美施康定对恶性肿瘤伴癌性疼痛患者的疼痛缓解效果及生活质量的影响。方法:75例癌症患者随机分为观察组与对照组。观察组予祛瘀消痛贴膏联合美施康定治疗,对照组仅给予美施康定。以疼痛数字评价量表(NRS)评分和生活质量(QOL)评分法于治疗前后评价患者的疼痛程度和生活质量,并记录治疗后药物起效时间及持续镇痛时间。定期随访,记录不良反应。结果:观察组持续镇痛时间和起效时间均优于对照组(P<0.05),NRS评分显著低于对照组(P<0.05);两组患者治疗前QOL评分差异无统计学意义,治疗后观察组QOL评分明显高于对照组(P<0.05);观察组临床症状总改善率高于对照组(P<0.05),不良反应发生率低于对照组(P<0.05)。结论:祛瘀消痛贴膏联合美施康定可缓解恶性肿瘤患者的癌性疼痛,患者不良反应小,并有助于提高患者生活质量。

Objective： To compare effects of Quyu Xiaotong plaster combined with morphine sulfate（ MST） on cancerous pain and quality of life. Methods： Seventy five patients were divided into research group and control group. Research group were treated by Quyu Xiaotong plaster and MST,while control group by MST only. After treatment,QOL method was used to evaluate the patients’ quality of life,and NRS was used to evaluate the degree of pain. The onset time of drugs after treatment and continuous analgesia time was recorded. Follow up was performed to observe side effects. Results： In the observation group,analgesia time and the onset time were more durable. Pain ratings significantly improved after treatment. After treatment, the observation group had a significantly lower pain score than the control group,which showed a better analgesic effect. In the same time,two treatments showed significant analgesic effects,and QOL score of observation group was significantly higher than that of the control group. Besides,patients’ clinical symptoms improved in observation group much better than those in the control group,the observation group showed better efficacy. Moreover,the incidence of adverse reactions in observation group was 23. 7%,while 54. 1% in the control group,with significant differences between the two groups. Conclusion： Quyu Xiaotong plaster combined with MST in treating cancerous pain can effectively control clinical symptoms with relative less adverse reaction.