骨感染患者并发菌血症的影响因素分析

Analysis of the influence factors of bone infection complicated with bacteremia

目的:探讨骨感染患者并发菌血症的高危因素。方法:采用病例对照研究设计,共收集87例骨感染并发菌血症患者和298例仅仅骨感染患者的资料。采用自制问卷调查一般人口学情况、吸烟史、饮酒史及健康相关疾病情况等信息,并采集患者静脉血和骨组织检测细菌种类判断是否发生菌血症和骨感染情况。采用Kruskal-Wallis检验方法和逐步多因素Logistic回归模型筛选出骨感染并发菌血症患者的高危因素。结果与结论:骨感染细菌种类为金黄色葡萄球菌的患者、骨髓炎患者、在抗生素治疗之前有发热的患者及骨感染并有免疫抑制类疾病患者更易发生全身的菌血症。临床医生应该尽早识别骨感染高危患者,减少菌血症的发生。

Objective： To explore risk factors of bone infection complicated with bacteremia. Methods： Using case-control study designing method,87 patients with bone infection complicated with bacteremia were collected,as well as 298 patients with bone infection only. Using self-designed questionnaire of general demographic situation,history of smoking,drinking and health related information such as illness,also venous blood and bone tissue were collected for the detection of bacteremia and bone infection. Using Kruskal Wallis test method and gradually multivariable logistic regression model,risk factors of bone infection complicated with bacteremia were selected. Results and Conclusion： This study has found out that patients with bone infection of staphylococcus aureus,patients with osteomyelitis,patients with fever prior antibiotics use and bone infection complicated with immunosuppressive diseases are more likely to have systemic bacteremia.