丁苯酞联合依达拉奉对急性脑梗死患者血清神经元特异性烯醇化酶和S-100β的影响及疗效评定

Effect of butylphthalide combined with edaravone on serum neuron specific enolase and S-100β in the patients with acute cerebral infarction

目的通过观察治疗前后患者血清神经元特异性烯醇化酶(NSE)和S-100β的变化,探讨丁苯酞联合依达拉奉治疗急性脑梗死的作用机制,从而评价其临床疗效。方法将114例急性脑梗死患者随机分为依达拉奉组、丁苯酞组和联合用药组,每组各38例,分别于治疗前、治疗后7 d及14 d测定其血清NSE和S-100β浓度,并进行临床神经功能缺损程度评分,并比较3组临床疗效。结果治疗后,3组均可降低急性脑梗死患者血清NSE和S-100β浓度,有效降低神经功能缺损评分,联合用药组效果更显著(P<0.05)。结论依达拉奉联合丁苯酞治疗急性脑梗死可明显降低患者血清NSE和S-100β浓度,有效降低神经功能缺损评分,促进神经功能的恢复,改善患者预后。

Objective To investigate the mechanism of butylphthalide combined with edaravone in treatment for acute cerebral infarction by observing the changes of serum NSE and S-100β before and after treatment. Methods 114 patients with acute cerebral infarction were randomly divided into edaravone group（ n = 38）,butylphthalide group（ n = 38）and edaravone combined with butylphthalide group（ n = 38）. The levels of serum NSE and S-100β on the day of admission,7 and 14 days after treatment were measured. The scales of nerve function defect degree on each group before and after treatment were detected,and the clinical efficacy was evaluated. Results After treatment,the serum levels of NSE and S-100β in all three groups were decreased,and the nerve function defect score was significantly decreased. Edaravone combined with butylphthalide treatment showed most significant effects（ P〈0. 05）. Conclusions Edaravone combined with butylphthalide in treating acute cerebral infarction can significantly reduce the serum levels of NSE and S-100β,and effectively promoting the recovery of nerve function,improving the prognosis of the patients.