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KLF4与原发性肝细胞癌关系的研究进展 被引量：1

Relationship between KLF4 and primary hepatocellular carcinoma
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摘要 KLFs家族是一类具有锌指结构的转录因子,参与多个生理活动的调控,在细胞增殖、凋亡、分化以及胚胎发育等过程中扮演了关键的角色,与真核基因转录调控密切相关.Kruppel样因子4(Kruppel like factor 4,KLF4)作为KLFs家族中重要的一员,KLF4在原发性肝癌组织中呈现高表达,但是KLF4在原发性肝细胞癌的作用机制仍需要进一步的探讨,本文就KLF4在原发性肝细胞癌中的生物学功能进行综述. Kruppel-like factors （KLFs） are a family of transcription factors with zinc finger structure, which play a key role in cell proliferation, apoptosis, differentiation and embryonic development. KLF4 is an important member of the KLF family, and it is highly expressed in primary hepatocellular carcinoma tissues. However, the mechanism of KLF4 in primary hepatocellular carcinoma remains to be explored. This paper reviews the biological function of KLF4 in primary hepatocellular carcinoma.
作者 冯潜 邬林泉
机构地区 南昌大学第二附属医院肝胆外科
出处 《世界华人消化杂志》 CAS 2016年第4期497-504,共8页 World Chinese Journal of Digestology
基金 江西省教育厅基金资助项目 No.GJJ14056~~
关键词 原发性肝细胞肝癌 Kruppel样因子4 侵袭转移 增殖 凋亡 Primary hepatocellular carcinoma Kruppellike factor 4, Invasion and metastasis Proliferation Apopt^s
分类号 R735.7 [医药卫生—肿瘤]
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参考文献56

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二级参考文献38

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世界华人消化杂志
2016年 第4期

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