白介素-27与炎症性肠病关系的研究进展

Role of interleukin-27 in inflammatory bowel disease

炎症性肠病是一组反复发生的慢性肠道非特异性炎症,其发病机制并不十分清楚,然而免疫调节异常被认为是该病发病的关键因素.白介素-27(interleukine-27,IL-27)是IL-12家族的新成员,主要由抗原提呈细胞产生,能够调节多种T细胞亚型的功能,并在感染及自身免疫性疾病中发挥重要的免疫调节作用.近年研究发现IL-27与炎症性肠病的发生、发展关系密切,本文就IL-27与炎症性肠病的关系作一综述.

Inflammatory bowel disease （IBD）, which is characterized by chronic or recurrent relapsing gastrointestinal inflmnn^tion, includes ulcerative colitis （UC） and Crohn＇s disease （CD）. The pathogenesis of IBD remains obscure, however, abnormal immune responses are regarded as the major component of IBD pathogenesis. Interleukin-27 （IL-27） is a new member of the IL-12 family, and it is produced by activated antigen-presenting cells and plays an important role in the differentiation and function of different T cell subsets. IL-27 has various immunoregulatory functions and is implicated in the pathogenesis of many infectious and autoimmune diseases. Recent studies have showed that IL-27 is strongly associated with the genesis and development of IBD. Here we provide an overview of the role of IL-27 in the pathogenesis of IBD.