2012-2014年龙岩市健康人群流脑抗体水平分析

Analysis on Antibody Level Against Cerebrospinal Meningitis in Healthy Population in Longyan from 2012 to 2014

目的了解龙岩市健康人群流脑抗体免疫水平,为制订流脑免疫工作计划提供科学依据。方法 2012-2014年采集部分健康人群血清,用酶联免疫吸附试验检测A群和C群流脑抗体水平。结果 3年健康人群A群、C群流脑阳性检出率逐年升高,A群抗体阳性率显著高于C群（χ~2=1 4 5.6 9,P〈0.0 1）。A群、C群均无性别间差异。A群抗体水平阳性率随着年龄增加呈上升趋势（χ_（趋势）~2=0.9 5,P〉0.0 1）。C群抗体水平3岁~组最高,5岁~组次之,〈1岁组A群和C群抗体阳性率均很低。结论龙岩市存在C群流脑暴发的可能,因此要加强C群流脑疫苗的预防接种,要特别关注〈1岁组人群。

Objective To survey the level of antibody to epidemic cerebrospinal meningitis among the healthy population in Longyan,and to provide the Scientific evidence for making the work plan. Methods The samples of venous blood were collected from healthy population from 2012 to 2014,and Enzyme-linked immunosorbent assay（ELISA）was used to detect the level of antibody to group A and group C epidemic cerebrospinal meningitis. Results The positive rate of group A and group C epidemic cerebrospinal meningitis were increased year by year in the three years. The positive rate of group A antibody was much higher than group C antibody（χ2 =145.69,P〈0.01）. Both group A and group C were no differences between the sexes. The positive rate of group A antibody was increased with age（χ2（趋势）=0.95,P〉0.0 1）. The positive rate of group C antibody in 3 age~ group was the highest and in 5 age~ group was the second of all age groups.The positive rates of group A and group C antibody among the children under 1 year old were relatively lower.Conclusion It is predicted that the outbreak or sporadic epidemic of group C cerebrospinal meningitis might happen. It is necessary to strengthen the measures for improve the inoculation of vaccine against C epidemic cerebrospinal meningitis,especially in low-aged children.