氯沙坦钾联合至灵胶囊治疗早期糖尿病肾病观察

Effect of losartan potassium combined with Zhiling Capsule on early diabetic nephropathy

目的观察氯沙坦钾联合至灵胶囊治疗早期糖尿病肾病的疗效。方法选取2014年6月-2015年1月期间中心收治的早期糖尿病肾病患者100例,随机分为两组各50例。对照组单独应用氯沙坦钾,观察组联合应用氯沙坦钾与至灵胶囊。观察两组患者治疗前后24 h尿微量清蛋白、肌酐及尿素氮改善情况。结果观察组在24h尿微量清蛋白、肌酐及尿素氮较对照组存在差异并且总有效率高于对照组,差异有统计学意义(P<0.05)。结论氯沙坦钾联合至灵胶囊治疗早期糖尿病肾病疗效确切。

Objective To observe the effect of losartan potassium combined with Zhiling Capsule in treatment of early diabetic nephropathy. Methods 100 patients with early diabetic nephropathy were randomly divided into two groups,with 50 cases each,at the center of 2014 June-2015 January. The control group were applied with losartan potassium alone,and the observation group were given losartan potassium and Zhiling Capsule. Two groups of patients were observed before and after treatment,by determination of 24 hours urinary albumin,creatinine and urea nitrogen. Results Observation group in 24 hours urinary microalbumin,creatinine and urea nitrogen compared with the control group,the differences and total efficiency is higher than that of the control group,difference was statistically significant（P〈0.05）. Conclusion Losartan Potassium combined with Zhiling Capsule in the treatment of early diabetic nephropathy is effective.