血清心肌肌钙蛋白T在冠心病介入治疗前后的变化与预后的关系

The Change of Serum Cardiac Troponin T Levels in Coronary Heart Disease before and after Interventional Therapy and Its Relationship with Prognosis

观察经皮冠状动脉介入治疗(PCI)术前后血清心肌肌钙蛋白T(cTnT)表达水平,探讨其与预后之间相关关系。80例冠心病患者均接受PCI,于术前、术后测定血清cTnT水平进行比较。冠心病患者PCI术后血清cTnT水平均明显升高(P<0.05)。术前血清cTnT水平≥0.1ng/ml组患者心血管事件发生率更高(P<0.05)。术后24h血清cTnT水平≥0.1ng/ml组心血管不良事件总发生率为25例(47.2%),显著高于D组5例(18.5%)(P<0.05)。术后cTnT水平升高≥2倍组心血管不良事件发生率更高(P<0.05)。PCI术后cTnT显著升高,且术前或者术后cTnT升高均对预测术后6个月心血管不良事件发生率具有一定价值。

To observe the changes of serum cardiac troponin T in patients with coronary heart disease （CHD） before and after percutaneous coronary intervention therapy, and to investigate the relationship with prognosis. 80 patients with the diagnosis of coronary heart disease were treated with PCI, both in the preoperative min and after extraction to determinate of serum level of cTnT to compare. The level of serum cTnT in patients with coronary heart disease after PCI was significantly higher （P〈0.05）. The patients with preoperative serum cTnT levels≥0.1ng/ml had higher cardiovascular events （P〈0.05）. The patients with postoperative serum cTnT levels≥0.1ng/ml incidence of adverse cardiovascular events was 25 cases （47.2%） and was higher than 5 cases （18.5%） of D group （P〈0.05）. The patients with serum cTnT levels≥2 had higher cardiovascular events （P〈0.05）. serum cardiac troponin T levels were significantly elevated in patients with coronary heart disease before and after percutaneous coronary intervention, and the level of serum cardiac troponin T before operation or after operation has predictive value for major adverse cardiovascular events 6 mouths after operation.