1400例肝硬化患者流行病学分析

Epidemiological analysis of 1 400 patients with cirrhosis

目的研究肝硬化患者临床资料,为肝硬化防治提供依据。方法选取2011年3月-2014年3月收治的1 400例肝硬化患者,回顾性分析其临床资料,并进行统计学处理。结果入组的1 400例肝硬化患者中,病毒性肝炎占64.3%,与酒精性肝硬化、非酒精性脂肪性肝炎、胆汁性肝硬化以及药物性肝炎患者相比,病毒性肝炎所致肝硬化患者比重最大,差异具有统计学意义（P〈0.05）。年龄为51岁~60岁的患者最多（35.9%）;农村地区发病率为65.9%,高于城镇（34.1%）,丙氨酸转氨酶显著升高者占86.4%;上消化道出血是肝硬化并发症中最常见的一种;治疗结果发现,好转率为73.1%,病死率为16.9%。结论病毒性肝炎是肝硬化的主要病因,应做好病毒性肝炎防治工作;积极应对肝硬化并发症有利于改善患者的生活质量。

Objective To study the clinical data of patients with cirrhosis,in order to provide the necessary basis for the prevention and treatment of cirrhosis. Methods 1 400 patients with cirrhosis were selected for the study from March 2011 to March 2014,clinical data were retrospectively analyzed,and the results data was statistically analyzed. Results Among the1 400 patients,900 cases were viral hepatitis,accounting for 64. 3%,higher than alcoholic cirrhosis,non- alcoholic steatohepatitis,biliary cirrhosis,drug- induced hepatitis,and there was statistical significance on the differences（ P〈0. 05）. The proportion aged between 51 to 60 years was the maximum（ 35. 9%）; the incidence in rural areas was 65. 9%,higher than the urban 34. 1%; alanine aminotransferase increased significantly,accounting for 86. 4%. The upper gastrointestinal bleeding was the most common in all kinds of complications of cirrhosis. The treatment results showed that improvement rate was 73. 1%,and mortality rate was 16. 9%. Conclusion Viral hepatitis is the main cause of liver cirrhosis,and the prevention and treatment of viral hepatitis should be done well; actively responding to liver cirrhosis complications are conducive to improving the quality of life of patients.