小柴胡汤改善抑郁症状及相关神经递质与神经营养因子分析

Effect of Xiaochaihutang on Patients with Depression Symtoms and Analysis on the Changes of Related Neurotransmitters and Neurotrophic factor

目的探索小柴胡汤对抑郁症状患者的疗效及脑内神经递质、神经营养因子变化关系。方法选取2013年4月~2015年4月于我院治疗的抑郁症状患者共计96例进行研究。按照入院顺序分为观察组和对照组,观察组患者应用小柴胡汤进行治疗,对照组患者应用西药进行治疗。观察两组患者治疗后的临床疗效及脑内神经递质、神经营养因子的变化。结果在接受治疗后,观察组患者的临床疗效显著,其总有效率达87.5%,明显高于对照组治疗后的总有效率41.67%,两组比较差异具有统计学意义（P〈0.05）。两组患者在接受治疗后均出现不同情况的副作用,但是观察组的不良反应发生率（4.17%）明显少于对照组的不良反应发生率（58.33%）,两组比较差异具有统计学意义（P〈0.05）;患者在应用小柴胡汤治疗后,两组患者的Ach、5-HT、NE及DA值在治疗前后差异具统计学意义（P〈0.05）,且在5-HT、NE及DA值方面,观察组较对照组变化更显著,在Ach上,两组患者治疗效果无显著统计学差异（P〉0.05）;两组患者治疗前后神经营养因子变化情况差异具有统计学意义（P〈0.05）,观察组患者的神经营养因子的变化较对照组更大。结论小柴胡汤治疗抑郁症状的临床疗效显著,有抗抑郁作用,并对脑内神经递质、神经营养因子有一定的影响。

Objective To analyze Xiaochaihutang efficacy and the changes of related neurotransmitters,neurotrophic factor in patients with depression. Methods 96 cases with depression symptoms in our hospital were selected from April 2013 to April 2015. According to their admission orders,they were divided into the observation group and the control group. The patients in the observation group were treated by Xiaochaihutang,and control group patients were given western medician. Clinical efficacy,changes of brain neurotransmitters,and neurotrophic factor were observed before and after treatment. Results After treatment,the total effective rate of patients in obsevation group 87. 5%,was significantly higher than the control group 41. 67%（ P〈0. 05）. Both of two groups have side effects,while the side effects in observation group was 4. 17%,it was statistically significantly less than the 58. 33%of the control group（ P〈0. 05）. With the application of Xiaochaihutang,on Ach,5-HT,NE and DA values,both groups of patients has significantly improved a lot compared with those before treatment（ P〈0. 05）,and on 5-HT,NE and DA value terms,the observation group has a better effect than the control group,about Ach,there was no statistically significant differences between two groups（ P〉0. 05）. The difference about neurotrophic factor of two groups of patients before and after the treatment were statistically significant（ P〈0. 05）,and the observation group has a better effect than the control group. Conclusion Xiaochaihutang can improve depression sympotoms,and regulate the neurotransmitters and neurotrophic factors.