刺五加注射液联合氟西汀治疗老年痴呆伴发抑郁的疗效分析

Curative effect of acanthopanex injection combined with fluoxetine in the treatment of senile dementia complicated with depression

目的评估刺五加注射液联合氟西汀治疗老年痴呆伴发抑郁症状的临床应用价值。方法将我院于2013年9月2015年3月期间118例老年痴呆伴发抑郁症状患者平均分成观察组和对照组,对照组采用氟西汀治疗,观察组在此基础上加用刺五加注射液治疗,对比两组患者治疗前后的汉密尔顿抑郁量表(HAMD)评分,并分别采用世界卫生组织生存质量量表(WHOQOL)和副反应量表(TESS)评估患者的生活质量和不良反应。结果治疗结束后,观察组的HAMD、WHOQOL均有显著变化,观察组的HAMD评分明显低于对照组(P<0.01),WHOQOL评分明显高于对照组(P<0.01)。两组患者治疗期间的TESS评分均无统计学差异(P>0.05)。结论刺五加注射液联合氟西汀可以缓解老年痴呆患者的抑郁情绪,提高患者的生存质量,且有较好的安全性,值得临床推广。

Objective To explore the curative effect of acanthopanex injection combined with fluoxetine in the treatment of senile dementia with depressive symptoms. Methods 118 cases of senile dementia complicated with depression patients who were treated in our hospital were divided into observation group and control group,the control group received fluoxetine,while the experimental group received acanthopanex injection combined with fluoxetine. Compare the HAMD score of these two groups pretherapy and post-treatment,and evaluate their life quality and adverse reaction with WHOQOL and TESS,respectively. Results After the treatment,there were significant changes in both HAMD and WHOQOL scores in both of these two groups,the HAMD score of observation group was markedly lower than control group＇s（ P〈0. 01）,WHOQOL score was significantly higher than control group（ P〈0. 01）,no statistical difference was observed in TESS score between the two groups（ P〈0. 05）. Conclusion Acanthopanex injection combined with fluoxetine could relief the depression emotion of senile dementia patients,and improve their life quality as well as have high security. Hence,acanthopanex injection combined with fluoxetine is worth of clinical application in the treatment of senile dementia complicated with depression.