甘草酸二铵肠溶胶囊联合水飞蓟宾胶囊治疗酒精性肝损伤疗效观察

Observation of curative effect by diammonium glycyrrhizinate enteric-coated capsules combined with silibinin capsules in the treatment of alcoholic liver injury

目的观察甘草酸二铵肠溶胶囊联合水飞蓟宾胶囊治疗酒精性肝损伤的疗效。方法 80例酒精性肝损伤患者,随机分为治疗组和对照组,各40例。治疗组应用甘草酸二铵肠溶胶囊联合水飞蓟宾胶囊治疗,对照组应用维生素C片联合水飞蓟宾胶囊治疗。观察比较两组治疗效果。结果治疗后,两组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)水平均较治疗前降低,差异均有统计学意义(P<0.05);且治疗组低于对照组,差异均有统计学意义(P<0.05)。治疗组总有效率92.5%优于对照组的80.0%,差异有统计学意义(P<0.05)。结论甘草酸二铵肠溶胶囊联合水飞蓟宾胶囊治疗酒精性肝损伤疗效确切,值得临床推广应用。

Objective To observe curative effect by diammonium glycyrrhizinate enteric-coated capsules combined with silibinin capsules in the treatment of alcoholic liver injury. Methods A total of 80 patients with alcoholic liver injury were randomly divided into treatment group and control group, with 40 eases in each group. The treatment group received diammonium glycyrrhizinate enteric-coated capsules combined with silibinin capsules for treatment, and the control group received vitamin C tablets combined with silibinin capsules for treatment. Curative effects of the two groups were observed. Results After treatment, both groups had decreased levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST） and gamma-glutamyl transpeptidase （GGT）, and their differences all had statistical significance （P〈0.05）. Those in the treatment group were all lower than those in the control group, and the differences all had statistical significance （P〈0.05）. The treatment group had better total effective rate as 92.5% than 80.0% of the control group, and the difference had statistical significance （P〈0.05）. Conclusion Combination of diammonium glyeyrrhizinate enteric-coated capsules and silibinin capsules provides precise effect in treating alcoholic liver injury, and it is worth clinical promotion and application.