类风湿关节炎患者血脂水平与疾病活动度的相关性研究

Correlation between Levels of Lipid Profile and Disease Activity in Rheumatoid Arthritis

目的:观察类风湿关节炎(RA)患者血脂的变化,以及血脂水平与疾病活动度之间的相关性。方法:对71例RA患者和77例正常对照的血脂水平进行回顾性分析,并对RA患者的血脂水平与其疾病活动度进行相关性分析。结果:RA患者的血清总胆固醇(TC)、甘油三酯(TG)水平均高于正常对照组(P<0.01),高密度脂蛋白(HDL)水平降低(P<0.01)。DAS28评分与TC(r=0.49,P<0.01)、TG(r=0.38,P<0.01)和LDL(r=0.55,P<0.01)呈正相关,与HDL呈负相关(r=-0.57,P<0.01),血沉与TC(r=0.26,P=0.03)、TG(r=0.28,P=0.02)呈正相关,C反应蛋白与TC(r=0.65,P<0.01)、TG(r=0.30,P=0.01)和LDL(r=0.39,P<0.01)均呈正相关。结论:RA患者存在血脂水平异常,且与疾病活动度相关。对血脂进行干预可能改善RA患者的长期预后。

Objective： To observe the changes ofserum lipids in rheumatoid arthritis（RA） patients and its correlation with the activity of this disease. Methods： This study was done on 71 RA patients and 77 normal controls. The lipid profile, ESR, CRP and DAS28 index were recorded by retrospective analysis. The correlation of lipid profile and disease activity was analyzed. Results： Compared with normal control group, the levels of total cholesterol（TC） and triglyceride（TG） in RA group were higher significantly（P〈0.01）, HDL level was lower（P〈0.01）. DAS28 index was correlated with the levels of TC（r=0.49, P〈0.01）, TG（r=0.38, P〈0.01）, LDL（r=0.55, P〈0.01） and HDL（r=-0.57, P〈0.01）. ESR was positively correlated with TC（r=0.26, P=0.03） and TG（r=0.28, P=0.02）; and CRP was positively correlated with TC（r=0.65, P〈0.01）, TG（r=0.30, P=0.01） and LDL（r=0.39, P〈0.01）. Conclusions： Dyslipidaemia was existed in RA patients and correlated with disease activity. The management of dyslipidaemia may improve the long-term outcomes in RApatients.