Flash双源CT冠脉成像联合心肌灌注显像对猪急性心肌梗死模型的诊断价值

Diagnostic Value of Flash Dual-source CT Coronary Imaging Combined with Myocardial Perfusion Imaging in Acute Myocardial Infarction Model of Pigs

目的:探讨Flash双源CT(DSCT)冠脉成像联合心肌灌注显像对猪急性心肌梗死模型的诊断价值。方法:使用明胶海绵栓塞法建立5只猪急性心肌梗死模型,使用DSCT冠脉成像联合心肌灌注显像进行"一站式"扫描得到冠脉图像和心肌灌注图像,并与冠脉造影和病理染色相比较。结果:DSCT得到的心肌灌注图像结果与病理染色相比较,敏感性为93%,特异性为91%,阴性预测值为96%,阳性预测值为84%,Kappa值为0.82;DSCT得到的冠脉图像与冠脉造影相比较,敏感性为93%,特异性为81%,阴性预测值为95%,阳性预测值为75%,Kappa值为0.71。结论:DSCT冠脉成像联合心肌灌注显像与组织病理学及冠脉造影一致性较好,可以用于对猪急性心肌梗死模型的诊断。

Objective： To investigate the diagnostic value of flash dual-source CT（DSCT）coronary imaging combined with myocardial perfusion imaging in acute myocardial infarction model of pigs. Methods： A total of 5 acute myocardial infarction models of pigs were cultured by means of gelatin sponge embolization, which were scanned by DSCT and ＂one-stop＂ generated coronary imaging and myocardial perfusion imaging and were compared with coronary angiography and pathology staining. Results： Compared with pathology staining, the results of myocardial perfusion imaging are as follows： the sensitivity was 93%, the specificity was 91%, the negative predictive value was 96%, the positive predictive value was 84%, and the Kappa value was 0.82; compared with coronary angiography, the results of coronary imaging are as follows： the sensitivity was 93%, the specificity was 81%, the negative predictive value was 95%, the positive predictive value was 75%, and the Kappa value was 0.71. Conclusion： DSCT coronary imaging combined with myocardial perfusion imaging is in a good consistency with coronary angiography and pathology staining, which can be used for the diagnosis of acute myocardial infarction model of pigs.