大小肾癌中CXCR4和MMP-3的表达及其临床意义研究

The Comparison of the Expression of CXCR4 and MMP-3 between Small and Large Renal Cell Carcinoma

目的:研究CXCR4及MMP-3的表达与大小肾癌生物学特性的关系。方法:在上海市第一人民医院泌尿外科2004年6月至2010年12月行手术治疗的肾癌患者里,任意抽出20例癌旁正常组织,30例小肾癌,30例大肾癌的标本,检验大小肾癌及正常肾组织中CXCR4及MMP-3的表达情况。结果:肾癌中CXCR4和MMP-3的表达高于癌旁正常肾组织(P<0.01),大肾癌CXCR4,MMP-3的表达高于小肾癌(P<0.05)。肾癌中两者的相关表达呈正相关。结论:MMP-3,CXCR4在小肾癌中的低表达可能预示了小肾癌恶性程度低、侵袭和转移能力小的生物学特点,可以预测肾癌的进展。

Objective： To research the relationship of biological characteristics between the large RCC and small RCC and the expression of MMP-3 and CXCR4. Methods： We chosed cases with small and large renal cell carcinoma from June 2004 to December 2010 in Shanghai NO.1 Hospital. The expression of CXCR4 and MMP-3 were detected by immunohistochemistry on normal renal tissue（20）,small RCC（30） and large RCC（30）. Results： The expressions of MMP-3 and CXCR4 in RCC are higher than in normal tissue（P〈0.01）.The expressions of MMP-3 and CXCR4 in large RCC is higher than in small RCC（P〈0.05）. It is positively related between the expressions of MMP-3 and CXCR4 in RCC. Conclusions： The lower expressions of MMP-3 and CXCR4 in small RCC may predict the less possibility of invasion and metastasis and less malignant in small RCC. MMP-3 and CXCR4 may be valuable for predicting prognosis of renal cell cancer.