小剂量激素联合环磷酰胺治疗系统性红斑狼疮患者的临床疗效

Clinical Efficacy of Small Dose Hormone Combined with Cyclophosphamide in the Treatment of Patients with Systemic Lupus Erythematosus

目的探讨小剂量激素联合环磷酰胺治疗系统性红斑狼疮(SLE)患者的临床疗效。方法选取2014年5月至2015年5月锦州市中心医院收治的60例SLE患者作为研究对象,按随机数字表法将其分为观察组和对照组,各30例。对照组患者采用小剂量激素进行治疗,观察组患者在对照组基础上联合静脉滴注环磷酰胺,比较两组患者的临床疗效及不良反应发生情况。结果观察组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者的不良反应发生率明显低于对照组,差异有统计学意义(χ2=4.800,P<0.05)。结论小剂量激素联合环磷酰胺治疗SLE患者安全有效,能减少不良反应发生。

Objective To analyze the clinical efficacy of small dose hormone combined with cyclophosphamide in the treatment of patients with systemic lupus erythematosus.Methods From May 2014 to May 2015,60 patients with SLE were randomly divided into observation group and control group by random number table method,30 cases in each group were randomly divided into observation group and control group.The control group was treated with small dose of hormone,the observation group were treated with intravenous cyclophosphamide on the basis of the control group,the clinical efficacy and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant（P〈0.05）;the incidence of adverse reactions in the observation group was significantly lower than that in the control group,the difference was statistically significant（χ2=4.800,P〈0.05）.Conclusion Small dose hormone combined with cyclophosphamide in the treatment of patients with SLE is safe and effective,can reduce the occurrence of adverse reactions.