丁苯酞联合胞二磷胆碱治疗急性脑梗死的临床研究

Clinical study on butylphthalide combined with citicoline in treatment of acute cerebral infarction

目的探究丁苯酞联合胞二磷胆碱治疗急性脑梗死的临床疗效。方法选取2014年1月—2014年12月商洛市中心医院神经内科收治的急性脑梗死患者100例,随机分为对照组和治疗组,每组各50例。对照组患者在基础治疗上静脉滴注胞二磷胆碱注射液,0.75 g/次,1次/d。治疗组患者在对照组治疗基础上口服丁苯酞软胶囊,0.2 g/次,3次/d。两组患者均连续治疗14 d。观察两组的临床疗效,同时比较治疗前后两组患者神经功能缺损程度(NIHSS)评分、神经元特异性烯醇化酶(NSE)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为74.0%、92.0%,两组比较差异有统计学意义(P<0.05)。治疗后,两组NIHSS评分、NSE水平均显著降低,同组治疗前后差异有统计学意义(P<0.05);治疗后治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论丁苯酞联合胞二磷胆碱治疗急性脑梗死具有较好的临床疗效,可促进神经功能的恢复,降低NSE水平,具有一定的临床推广应用价值。

Objective To study the treatment effect of butylphthalide combined with citicoline in treatment of acute cerebral infarction. Methods Patients（100 cases） with acute cerebral infarction in Department of Neurology of Shangluo Central Hospital from January 2014 to December 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were iv administered with Citicoline Injection on the basis of foundation treatment, 0.75 g/time, once daily. The patients in the treatment group were po administered with Butylphthalide Soft Capsules on the basis of control group, 0.2 g/time, three times daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of NIHSS score and NSE in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.0% and 92.0%, respectively, and there were differences between two groups（P〈0.05）. After treatment, NIHSS score and NSE in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Butylphthalide combined with citicoline has clinical curative effect in treatment of acute cerebral infarction, and can promote the recovery of neural function, also can decrease the NSE level, which has a certain clinical application value.