曲克芦丁脑蛋白水解物和脑苷肌肽治疗新生儿缺氧缺血性脑病的疗效比较

Comparison on clinical efficacy between troxerutin and cerebrprotein hydrolysate and cattle encephalon glycoside and ignotin in treatment of neonatal hypoxic ischemic encephalopathy

目的比较曲克芦丁脑蛋白水解物和脑苷肌肽治疗新生儿缺氧缺血性脑病的临床疗效。方法收集2013年1月—2015年1月在东方医院诊治的新生儿缺氧缺血性脑病患者120例,随机分为对照组和治疗组,每组各60例。对照组静脉滴注脑苷肌肽注射液,2 m L加入到5%葡萄糖注射液50 m L中,1次/d。治疗组静脉滴注曲克芦丁脑蛋白水解物注射液,0.5m L/(kg·d)加入到5%葡萄糖注射液50 m L中。两组均连续治疗14 d。观察两组的临床疗效,同时比较两组新生儿行为神经(NBNA)评分、意识恢复时间、肌张力恢复时间和原始反射恢复时间。对患儿进行6个月随访,记录两组患儿恢复正常,发生智力低下、癫痫、脑瘫的情况。结果治疗后,对照组和治疗组的总有效率分别为86.67%、95.00%,两组比较差异具有统计学意义(P<0.05)。两组患儿治疗3、7、14天NBNA评分比较差异均无统计学意义。治疗组患儿意识恢复时间、肌张力恢复时间、原始反射恢复时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组患儿恢复率显著高于对照组,智力低下发生率、癫痫发生率、脑瘫发生率均低于对照组,两组比较差异具有统计学意义(P<0.05)。结论曲克芦丁脑蛋白水解物注射液治疗新生儿缺氧缺血性脑病的临床效果显著,可缩短临床恢复时间,显著改善患儿随访结果,具有一定的临床推广应用价值。

Objective To compare the clinical effect of Troxerutin and Cerebrprotein Hydrolysate Injection and Cattle Encephalon Glycoside and Ignotin Injection in treatment of neonatal hypoxic ischemic encephalopathy. Methods Patients（120 cases） with neonatal hypoxic ischemic encephalopathy in Dongfang Hospital from January 2013 to January 2015 were randomly divided into control and treatment groups, and each group had 60 cases. The patients in the control group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection, 2 m L added into 5% Glucose Injection 50 m L, once daily. The patients in the treatment group were iv administered with Troxerutin and Cerebrprotein Hydrolysate Injection, 0.5 m L/（kg·d） added into 5% Glucose Injection 50 m L. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and NBNA scores, consciousness recovery time, muscle tone recovery time and primitive reflex recovery time in two groups were compared. Two groups were follow-up for 6 months, the occurrences of back to normal, low intelligence, epilepsy, cerebral palsy in two groups were recorded. Results After treatment, the clinical efficacies in the control and treatment groups were 86.67% and 95.00%, respectively, and there were differences between two groups（P〈0.05）. There was no difference between two groups about NBNA score in 3, 7, 14 day of treatment. The consciousness recovery time, muscle tone recovery time and primitive reflex recovery time in treatment was shorter than those in the control group, and there were differences between two groups（P〈0.05）. The recovery rate in the treatment group was significantly higher than that in the control group, and the incidences of low intelligence, epilepsy, cerebral palsy in the treatment group were significantly lower than those in the control group, and there were differences between two groups（P〈0.05）. Conclusion Troxerutin and Cerebrprotein Hydrolysate Injection has clinical curative effect in treatment of neonatal hypoxic ischemic encephalopathy, and can shorten clinical recovery time, also can significantly improve follow-up results, which has a certain clinical application value.