E-cadherin和巢蛋白在鼻咽癌组织中的表达及临床意义

Expression and clinical significance of E-cadherin and Nestin in nasopharyngeal carcinoma

目的研究E-钙黏蛋白(E-cadherin)、巢蛋白、Ki67和P53在鼻咽癌组织中的表达及其临床意义。方法应用免疫组织化学方法检测E-cadherin、巢蛋白、Ki67和P53在鼻咽癌组织(鼻咽癌组)和鼻咽炎组织(对照组)中的表达情况,并分析E-cadherin和巢蛋白的表达与鼻咽癌临床病理参数的关系。结果在鼻咽癌组织中E-cadherin和巢蛋白阳性表达率分别为11.63%和69.77%,在鼻咽炎组织中的阳性表达率分别为85.72%和9.52%,2组比较差异均有统计学意义(P均<0.05);Ki67和P53在鼻咽癌组织中的阳性表达率分别为93.02%和88.37%,在鼻咽炎组织中的阳性表达率分别为9.52%和4.76%,2组比较差异均有统计学意义(P均<0.05)。E-cadherin在有淋巴结转移组和无淋巴结转移组的阳性表达率分别为3.33%和30.77%,巢蛋白在有淋巴结转移组和无淋巴结转移组的阳性表达率分别为90.00%和23.08%,2组比较差异均有统计学意义(P均<0.05),E-cadherin和巢蛋白的表达与其他病理参数无关(P>0.05);巢蛋白的表达与E-cadherin的表达呈负相关(P<0.01)。结论 E-cadherin和巢蛋白的表达与鼻咽癌淋巴结的转移有一定关系,两者有可能通过共同作用影响鼻咽癌的转移。

Objective To investigate the expression and clinical significance of E-cadherin,Nestin,Ki67 and P53 in nasopharyngeal carcinoma. Methods The expression E-cadherin,Nestin,Ki67 and P53 in nasopharyngeal carcinoma（ nasopharyngeal carcinoma group） and nasopharyngitis tissues（ control group） were detected by immunohistochemical staining. The relationship between E-cadherin and Nestin and clinicopathological parameters was analyzed. Results The positive rate of E-cadherin and Nestin expression in nasopharyngeal carcinoma group were 11. 63% and 69. 77%,significantly differing from 85. 72% and 9. 52% in the control group（ both P〈0. 05）. The positive rate of Ki63 and P53 in the nasopharyngeal carcinoma group was93. 02% and 88. 37%,significantly higher compared with 9. 52% and 4. 76% in the control group（ both P〈0. 05）. The positive rate of E-cadherin expression was 3. 33% and 30. 77% in patients with and without lymph node metastasis,and the Nestin expression were 90. 00% and 23. 08% for the Nestin expression with statistical significance（ all P〈0. 05）. The expression of E-cadherin and Nestin was not correlated with alternative pathological parameters（ both P〉0. 05）. The expression of E-cadherin was negatively associated with Nestin expression（ P〈0. 01）. Conclusion The expression of E-cadherin and Nestin was correlated with the lymph node metastasis of nasopharyngeal carcinoma,which probably together affects the metastasis of nasopharyngeal carcinoma.